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The swabs were transferred to transport medium and sent to the microbiology lab of Shahid Beheshti University of Medical Science for isolation of bacterial strains. The 2 patients used silver sulfadiazine, trimethoprim sulfamethoxazole, TMP/SMX, and ceftazidime as medication. In September 2015 and June 2016, 2 swab samples from burn wound infections of a 64 year old woman as well as a 54-yr-old woman, who had been hospitalized in Motahari hospital (Iran University of medical sciences, Tehran, Iran) for a third-degree burning, were taken. Here, we report emergence of bla NDM-1- producing E. However, the appearance of carbapenemases gene, especially bla NDM-1, can be a serious risk factor in increasing carbapenem resistance rates among the E. coli isolates to imipenem was reported as 99.3% ( 7) and 100% ( 8). In 2 recent studies, the susceptibility of E. coli strains isolated from Iran is very low. The prevalence of carbapenem-resistant E. Today, bla NDM-1was detected in other bacterial species including Escherichia coli ( E. For the first time, bla NDM-1was detected from Klebsiella pneumonia isolated from a urinary tract sample from a Swedish patient who had been hospitalized in India ( 5). One of the most important carbapenemases is recently known as New Delhi metallo-β-lactamase-1 ( bla NDM- 1), which belongs to class B β-lactamases or metallo-β-lactamases (MBL) ( 4). CRE infections are associated with a high mortality rate ( 3). Unfortunately, today, the emerging of Carbapenemase-Producing Enterobacteriaceae (CPE) or Carbapenem-Resistant Enterobacteriaceae (CRE) is a concern in the treatment of multidrug-resistant Gram-negative infections ( 2).
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Therefore, early identification of these isolates is mandatory.Ĭarbapenems, including imipenem (IMP), meropenem (MEM), and ertapenem (ERP) are the last resort for extended-spectrum β-lactamases (ESBLs) producing bacteria ( 1). coli is a new threat for to the health system in Iran, due to the spreading of the bla NDM-1gene among pathogenic bacteria, which resulted in the emergence of multi drug resistant photogenes. Further sequencing of PCR products confirmed the presence of the bla NDM - 1gene in these isolates. However, genetic detection using Polymerase Chain Reaction amplification with specific primers for bla KPC, blaI MP, bla VIM - 1, bla VIM - 1 – bla VIM - 37, and bla NDM - 1genes showed that only the bla NDM - 1gene is amplified from the resistant isolates.
![cid new episode 30 september 2015 cid new episode 30 september 2015](https://treeaware444.weebly.com/uploads/1/2/6/9/126985563/275992745.png)
Combined Disk Test showed that the isolates could not produce bla AmpC and bla KPC carbapenemase, whereas they can produce metallo-β-lactamases (MBL). The isolates were resistant to carbapenems (imipenem, meropenem and ertapenem) and other common antibiotics except nitrofurantoin. coli strains were isolated from 2 burn wounds of patients in the Motahari hospital, Tehran. Here, we report the appearance of bla NDM-1producing Escherichia coli ( E. Unfortunately, global emerging and spreading of carbapenemase, especially New Delhi metallo β lactamase 1 ( bla NDM-1), is a concern in the treatment of multi drug-resistant agents. Carbapenems are a broad-spectrum class of beta-lactam antibiotics, which are used in treatment of multi-drug resistant infections.